Non-invasive assessment of coronary inflammation improves the diagnostic accuracy of coronary death in post-mortem CT angiography.

Cheng Xie¹, Tina MacKinnon², Peter Cox², Sheena Thomas¹, Giacomo Galuppi², Sathees Kuttappan², David Freeman³, Rachel Benamore², Zoe Traill², Ileana Badi⁴, Bowen Xiao⁴, Elizabeth Wahome⁴, Rafail Kotronias¹, Kenneth Chan¹, Chris Mathers⁵, Pete Tomlins⁵, Eve Fryer⁶, Claire Robinson⁷, Aparna Deshpande⁷, Bruno Morgan⁷, Cheerag Shirodaria⁴, Ian Roberts⁶, Keith M Channon⁴, Stefan Neubauer⁴, Charalambos Antoniades⁸

¹Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, West Wing Level 6, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK; Acute Multidisciplinary Imaging & Interventional Centre, Radcliffe Department of Medicine, University of Oxford, Level 2 John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK.

²Radiology Department, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Headley Way, Oxford, OX3 9DU, UK.

³Oxfordshire Coroner's Office, The Oxford Register Office, 1 Tidmarsh Lane, Oxford, UK.

⁴Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, West Wing Level 6, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK.

⁵Caristo Diagnostics Ltd, Oxford, UK.

⁶Cellular Pathology Department, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Headley Way, Oxford, OX3 9DU, UK.

⁷Radiology Department, Leicester Royal Infirmary, Leicester, UK.

⁸Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, West Wing Level 6, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK; Acute Multidisciplinary Imaging & Interventional Centre, Radcliffe Department of Medicine, University of Oxford, Level 2 John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK. Electronic address: charalambos.antoniades@cardiov.ox.ac.uk.

PubMed DOI

Abstract

BACKGROUND: Post-mortem computed tomography (PMCT) is becoming the preferred method to diagnose the cause of death over autopsy. There are areas improvements for the technique. This study investigates the use of a minimally invasive procedure under imaging guidance to perform PMCT Angiography (PMCTA), and coronary inflammation assessment to identify coronary death to aid the radiologists' diagnosi…

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