A thermally actuated 3D foldable bioelectronic interface for multimodal electrophysiological and cytokine profiling of human spinal cord organoids.

Seungjun Lee¹, Sangmin Han², Hyogeun Shin³, Ju-Hyun Lee⁴, Namsun Chou⁵

¹School of Electronic and Electrical Engineering, Kyungpook National University, Daegu, 41566, Republic of Korea; Emotion, Cognition & Behavior Research Group, Korea Brain Research Institute (KBRI), Daegu, 41062, Republic of Korea.

²Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Department of Biomedical Sciences, Korea University College of Medicine, Seoul, 02841, Republic of Korea.

³School of Electronic and Electrical Engineering, Kyungpook National University, Daegu, 41566, Republic of Korea; School of Electronics Engineering, College of IT Engineering, Kyungpook National University, Daegu, 41566, Republic of Korea; Brain Science and Engineering Institute, Kyungpook National University, Daegu, 41566, Republic of Korea. Electronic address: hyogeunshin@knu.ac.k.

⁴Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST), Seoul, 02792, Republic of Korea.

⁵Emotion, Cognition & Behavior Research Group, Korea Brain Research Institute (KBRI), Daegu, 41062, Republic of Korea; Graduate School, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea. Electronic address: nschou@kbri.re.kr.

PubMed DOI

Abstract

Three-dimensional (3D) organoids provide physiologically relevant models for studying human neural development and disease; however, stable bioelectronic interfacing with curved and dynamic organoid surfaces remains challenging. Here, we present a thermally actuated, shape-memory polymer (SMP)-based foldable bioelectronic interface for simultaneous electrophysiological recording and electrochemica…

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