Report of high data rate macromolecular crystallography (HDRMX) meeting, 23 July 2025.

Christine Beavers¹, Herbert J Bernstein², Aaron S Brewster³, Max Burian⁴, Nicholas Devenish⁵, Jiaxin Dawn Duan⁶, Daniel Eriksson⁷, Diego Gämperle⁴, Yang Ha³, David R Hall⁵, James Holton⁸, Peter Keller⁹, Loes Kroon-Batenburg¹⁰, David W Mittan-Moreau³, Yasukazu Nakaye¹, Daniel W Paley³, Ezra Peisach¹¹, Nicholas K Sauter³, Sofia Trampari⁴, Clemens Vonrhein¹², David G Waterman¹², Thomas A White¹³, Graeme Winter¹⁴

¹Rigaku Americas, The Woodlands, Texas 77381, USA and Rigaku Corporation, Akishima, Tokyo 196-8666, Japan.

²Ronin Institute for Independent Scholarship 2.0, c/o NSLS II, BNL, Upton, New York, 11973-5000, USA.

³Lawrence Berkeley National Laboratory, Berkeley, California, 94720, USA.

⁴DECTRIS Ltd., Baden, Aargau, Switzerland.

⁵Diamond Light Source, Chilton, United Kingdom.

⁶Paul Scherrer Institute, Villigen, Switzerland.

⁷Crystallography Group, Australian Synchrotron, ANSTO, Clayton, Melbourne, VIC 3168, Australia.

⁸Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158-2330, USA; Division of Molecular Biophysics and Bioengineering, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA; and Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California 94025, USA.

⁹Global Phasing Limited, Cambridge, United Kingdom.

¹⁰Universiteit Utrecht, Utrecht, Netherlands.

¹¹Research Collaboratory for Structural Bioinformatics PDB, Piscataway, New Jersey, 08854-8076, USA.

¹²Research Complex at Harwell, UKRI-STFC Rutherford Appleton Laboratory, Harwell, Didcot, Oxfordshire OX11 0FA, United Kingdom.

¹³Deutsches Elektronen-Synchrotron DESY, Hamburg, Germany.

¹⁴Northeastern Collaborative Access Team (NE-CAT) Facility, Advanced Photon Source at Argonne National Laboratory, Lemont, Illinois, 60439, USA.

PubMed PMC DOI PDF

Abstract

This paper is a report of the High Data Rate Macromolecular Crystallography workshop held on 23 July 2025 as part of the 2025 meeting of the American Crystallographic Association in Lombard, IL, USA, 18-23 July 2025. This report summarizes the discussions, questions, action items, and recommendations that arose from the meeting and includes links to the presentations. The sessions were moderated b…

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