Peer-Reviewed Publication
JAMA Ophthalmol2026June 25, 2026Journal Article
Neuroretinal Layer Thinning on OCT Imaging and Hemoglobin A1c in Youth With Type 1 Diabetes.
Supriya Ramanujam1, Roomasa Channa2, T Y Alvin Liu3, Elizabeth A Brown1, Neha Parimi1, Yoohee Claire Kim1, Lee Bromberger1, Harold P Lehmann4, Michael D Abramoff5,6,7,8,9, Risa M Wolf1
1Division of Endocrinology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland.
2Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison.
3Wilmer Eye Institute at the Johns Hopkins School of Medicine, Baltimore, Maryland.
4Section on Biomedical Informatics and Data Science, Johns Hopkins University, Baltimore, Maryland.
5Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City.
6Digital Diagnostics, Coralville, Iowa.
7Iowa City VA Medical Center, Iowa City, Iowa.
8Department of Biomedical Engineering, The University of Iowa, Iowa City.
9Department of Electrical and Computer Engineering, The University of Iowa, Iowa City.
Abstract
IMPORTANCE: Diabetic retinal neurodegeneration precedes vascular changes associated with diabetic retinal disease (DRD). Studies in adults with type 1 diabetes (T1D) show there is retinal layer thinning with DRD, yet there are limited data in youth with T1D.
OBJECTIVES: To determine if retinal layer thickness changes on optical coherence tomography (OCT) imaging were associated with glycemic outc…
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