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Acta Crystallogr D Struct Biol2026;82(Pt 7):813-823.July 1, 2026Journal Article

Scotty: lattice coincidences for macromolecular crystallographic phasing.

Airlie J McCoy1, Lawrence C Andrews2, Herbert J Bernstein3, Randy J Read1
1Cambridge Institute for Medical Research, Department of Haematology, University of Cambridge, The Keith Peters Building, Hills Road, Cambridge CB2 0XY, United Kingdom.
2Ronin Institute for Independent Scholarship 2.0, 9515 NE 137th Street, Kirkland, WA 98034, USA.
3Fresh Pond Research Institute c/o Brookhaven National Laboratory, NSLS II, Upton, NY 11973, USA.
PubMed PMC DOI PDF

Abstract

When a macromolecular crystal lattice targeted for study is closely related to a previously studied crystal lattice, phasing the target crystal by difference (fast-)Fourier transform (DFFT) methods is preferable to performing molecular replacement. The application Scotty, within the Phasertng codebase, is software for the identification of coincident lattices and downstream processing. All crystal…

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