Successful treatment of idiopathic multicentric Castleman disease with TAFRO and kidney involvement: case report and literature review.

Ahmed I Kamal¹, Hima Doppalapudi², Thien Ho¹, Salem Vilayet¹, Vishu Pasham³, Milos Budisavljevic¹, Anand Achanti¹

¹Internal Medicine Department, Nephrology Division, Medical University of South Carolina, Charleston, SC, USA.

²Mercy Medical Center, Cedar Rapids, IA, USA.

³Pathology and Laboratory Medicine Department, Medical University of South Carolina, Charleston, SC, USA.

PubMed PMC DOI PDF

Abstract

Idiopathic multicentric Castleman disease (iMCD) is a rare hematological disease of heterogenous presentation, with symptoms ranging from mild to severe and life-threatening. A severe subtype of iMCD is characterized by thrombocytopenia, anasarca (including pleural effusion and ascites), fever, reticulin myelofibrosis or renal dysfunction, and organomegaly (iMCD-TAFRO). Early identification and tr…

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