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Peer-Reviewed Publication
Otolaryngol Head Neck Surg2026June 17, 2026Journal Article

The Molecular Heterogeneity of NRAS Variants in Thyroid Nodules.

Emma De Ravin1, Mohammed Alshalalfa2, Ruochen Jiang2, Yangyang Hao2, Joshua P Klopper2, Elizabeth Cottrill1
1Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
2Veracyte Inc., South San Francisco, California, USA.
PubMed DOI

Abstract

OBJECTIVE: NRAS variants are the most common mutations in thyroid nodules with (B)ethesda III/IV cytology. This study aims to characterize co-occurring variants, molecular signatures, and hallmarks of cancer pathways in nodules with NRAS variants. STUDY DESIGN: Retrospective database analysis. METHODS: The database of nodules sent for Afirma GSC testing was analyzed for the most common NRAS hots…

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