Health AI Central
Peer-Reviewed Publication
Arq Bras Cardiol2026;123(4):e20250650.April 1, 2026Journal Article

Artificial Intelligence-Derived ECG-Age as a Predictor of Mortality and Cardiovascular Events: A Systematic Review and Meta-Analysis.

Isadora Cristine Reis Sguizzato Bozzi1,2, Maria Clara de Araujo Gontijo Lima2, Antonio Luiz Pinho Ribeiro1,2, Gabriela Miana de Mattos Paixão1,2
1Centro de Telessaúde, Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, MG - Brasil.
2Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, MG - Brasil.
PubMed DOI

Abstract

BACKGROUND: Artificial intelligence (AI)-derived electrocardiographic age (ECG-age) and the difference between ECG-age and chronological age (delta-age) are emerging biomarkers of cardiovascular aging and adverse outcomes, but their prognostic value remains unclear. OBJECTIVES: We performed a systematic review and meta-analysis to evaluate associations between AI-derived ECG-age or delta-age and…

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