Peer-Reviewed Publication
Am J Prev Cardiol2026;27101457.June 1, 2026Journal Article
The impact of post-acute sequelae of COVID-19 on cardiac function and structure: A systematic review and a hybrid individual participant data meta-analysis.
Binyam Tariku Seboka1,2, Lillian Ma3, Dianna J Magliano4,3, Stella Talic5, Antonio da Silva Menezes Junior6, Alessandra Borlotti7, Helena Thomaides Brears7, Andrea Dennis7, Amitava Banerjee8, Thomas H Marwick1,2,9, Quan Huynh1,2,9
1Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Victoria, Australia.
2Imaging Research Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
3School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
4Diabetes and Population Health, Baker Heart and Diabetes Institute, Melbourne, Australia.
5Monash University, Clinical Epidemiology and Pharmacoepidemiology, Australia.
6Faculty of Medicine, Federal University of Goiás, Brazil.
7Perspectum Diagnostics, United Kingdom.
8Institute of Health Informatics, University College London, United Kingdom.
9Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Abstract
BACKGROUND: Post-acute sequelae of SARS-CoV-2 infection (PASC), also referred to as Long COVID, affect a significant proportion of COVID-19 survivors, with evidence suggesting cardiovascular involvement. However, the nature, extent, and clinical significance of these alterations remain uncertain.
AIM: To synthesize evidence on structural and functional cardiac alterations in individuals with PASC…
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