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Am J Prev Cardiol2026;27101453.June 1, 2026Journal Article

Epicardial adipose tissue signatures in Asian coronary artery disease: Insights from cardiac CT.

Xiaomeng Wang1, Liang Zhong1,2, Swee Yaw Tan1,2, Lynette Li San Teo3, Weimin Huang4, Hwee Kuan Lee5,6,7,8,9, Shuang Leng2,10, Yan Ting Loong2, Nur Amirah Syahindah Raffiee2, Sock Hwee Tan11, Thon Hon Yong12, Min Sen Yew13, Ching Hui Sia14,11, Mayank Dalakoti15,16,17, Leslee J Shaw18, Eugene Yang19, Mark Yan Yee Chan14,11, Derek J Hausenloy1,20,11,21, Lohendran Baskaran2,20,10,22,1
1Cardiovascular and Metabolic Disorders Programme, Duke-National University of Singapore, Singapore, Singapore.
2National Heart Center Singapore, Singapore, Singapore.
3Department of Diagnostic Imaging, National University Hospital, Singapore, Singapore.
4Institute for Infocomm Research, Agency for Science, Technology and Research (A*Star), Singapore, Singapore.
5Bioinformatics Institute, Agency for Science, Technology and Research (A*Star), Singapore, Singapore.
6School of Computing, National University of Singapore, 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Singapore.
7School of Biological Sciences, Nanyang Technological University, Singapore 639798, Singapore.
8International Research Laboratory on Artificial Intelligence, Singapore 138632, Singapore.
9Centre for Frontier AI Research (CFAR), Agency for Science, Technology and Research (A*Star), 1 Fusionopolis Way #16-16 Connexis (North Tower), Singapore 138632, Singapore.
10Duke-National University of Singapore, Singapore, Singapore.
11Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
12Department of Cardiology, Changi General Hospital, Singapore, Singapore.
13Department of Cardiology, Tan Tock Seng Hospital, Singapore, Singapore.
14National University Heart Center Singapore, Singapore, Singapore.
15Department of Cardiology, National University Heart Center Singapore, Singapore, Singapore.
16Cardiovascular Metabolic Translational Research Program, National University of Singapore, Singapore.
17British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
18Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, 10029, USA.
19Division of Cardiology, University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195, USA.
20National Heart Research Institute Singapore, National Heart Center Singapore, Singapore, Singapore.
21Cardiovascular Disease National Collaborative Enterprise (CADENCE), Singapore 139234, Singapore.
22CVS.AI, National Heart Research Institute Singapore, National Heart Center Singapore, Singapore, Singapore.
PubMed PMC DOI PDF

Abstract

OBJECTIVES: We aim to compare cardiac CT characteristics of epicardial adipose tissue (EAT), coronary plaque, and perivascular adipose tissue (PVAT) among East, South and Southeast Asian coronary artery disease (CAD) patients. METHODS: This retrospective, cross-sectional study analyzed data from 2702 stable CAD patients, including 2078 East (56.4 ± 11.2 years, 59.5% male), 310 South (53.2 ± 10.4…

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