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Peer-Reviewed Publication
Diabetes Technol Ther2026;15209156261459741.June 12, 2026Journal Article

Engagement with an AI- and CGM-Integrated Digital Health Platform Is Associated with Clinically Significant Weight Loss.

William Dixon1, Stephanie Kim2, Grace E Shryack1, Dmitri Levonian1, Dan Gusz1, Sharam Fouladgar-Mercer1, Jay S Skyler3
1Signos, Palo Alto, California, USA.
2University of Washington, Seattle, Washington, USA.
3Diabetes Research Institute, University of Miami, Miami, Florida, USA.

Abstract

BACKGROUND: Obesity affects millions of U.S. adults and is linked to cardiometabolic disease. This study examined whether user engagement with the Signos app, which combines artificial intelligence (AI) and continuous glucose monitoring (CGM), is associated with weight loss. METHODS: This study included adults (≥18 years) with BMI ≥ 30 kg/m2 and without diabetes who enrolled in the Signos System,…

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