Anxiety-related behavioural responses to light-dark transitions in zebrafish larvae treated with a Withaniasomnifera (L.) Dunal water extract and selected withanolides.

Aboobakr Sakoor¹, Krystyna Skalicka-Woźniak², Barbara Budzyńska³, Weiyang Chen¹, Clement Agoni⁴, Maxleene Sandasi⁵, Gill Enslin¹, Son Hung Tran⁶, Kyungsu Kang⁶, Alvaro Viljoen⁷

¹Department of Pharmaceutical Sciences, Tshwane University of Technology, Private Bag X680, Pretoria, 0001, South Africa.

²Department of Chemistry of Natural Products, Medical University of Lublin, 1 Chodzki Street, Lublin, 20-093, Poland.

³Independent Laboratory of Behavioural Studies, Medical University of Lublin, Chodzki Street, Lublin, 20-093, Poland.

⁴Department of Pharmaceutical Sciences, Tshwane University of Technology, Private Bag X680, Pretoria, 0001, South Africa; Discipline of Pharmaceutical Sciences, School of Health Sciences, Westville Campus, University of KwaZulu-Natal, Durban, 4001, South Africa; National Institute for Theoretical and Computational Sciences (NITheCS), Stellenbosch, South Africa.

⁵Department of Pharmaceutical Sciences, Tshwane University of Technology, Private Bag X680, Pretoria, 0001, South Africa; SAMRC Herbal Drugs Research Unit, Faculty of Science, Tshwane University of Technology, Pretoria, 0001, South Africa.

⁶Center for Natural Product Systems Biology, Korea Institute of Science and Technology, Gangneung, Gangwon-do, 25451, South Korea; Natural Product Applied Science, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do, 25451, South Korea.

⁷Department of Pharmaceutical Sciences, Tshwane University of Technology, Private Bag X680, Pretoria, 0001, South Africa; SAMRC Herbal Drugs Research Unit, Faculty of Science, Tshwane University of Technology, Pretoria, 0001, South Africa. Electronic address: viljoenam@tut.ac.za.

PubMed DOI

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE: Withania somnifera (L.) Dunal (Solanaceae) is used traditionally for anxiety; however, the activity of the distilled-water root extract and its major withanolide constituents remains incompletely characterised in larval zebrafish. AIM OF THE STUDY: To evaluate the anxiolytic-like effects of a distilled-water root extract and selected withanolides in a larval zebraf…

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