Chemically induced skin tumors arise from long-lived stem cells of the upper hair follicle.

Eve Kandyba¹, Arnaud Jabouille¹, Ferriol Calvet², Yun Rose Li^1,3,4, Andrea Curtabbi¹, Diana Cristea¹, Joyce Shin¹, Reyno Delrosario¹, Jonathan Anzules³, Di Wu¹, David Quigley¹, Mark Taylor¹, Camila Zanette⁵, Fang Yin Lo^5,6, Jacob Higgins⁵, Jesse Salk⁵, Nuria Lopez-Bigas^2,7,8,9, Allan Balmain¹

¹Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.

²Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.

³Department of Radiation Oncology and Cancer Genetics and Epigenetics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.

⁴Division of Bioinnovation and Genome Sciences, Translational Genomics Research Institute, Phoenix, AZ, USA.

⁵TwinStrand Biosciences, Seattle, WA, USA.

⁶Generate Biomedicines, Somerville, MA, USA.

⁷Centro de Investigación Biomédica en Red en Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain.

⁸Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain.

⁹Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

PubMed DOI

Abstract

The identification of the cancer cell of origin is a fundamental question in cancer biology. We used fluorescent lineage tracing of independent mouse skin stem cell populations, single cell transcriptomics, and Duplex sequencing, to identify the origin of chemically induced skin tumors. Tumors arose predominantly from Lgr6+ and / or Lrig1+ stem cells of the upper hair follicle, but only very rarel…

Create a free account to keep reading

Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.

Create Free Account Sign In

Want unlimited research access? See Pro plans

Mentioned Companies

Generate Biomedicines
affiliation

NIH Funding

Grant #11175735
PROMINENT - IRB
FUNDACIO INSTITUT DE RECERCA BIOMEDICA
$102,979 (FY2024)
Grant #11539612
PROMINENT - UCSF
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
$2,222,832 (FY2026)
Grant #9063479
Genetic network analysis of cancer targets
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
$308,486 (FY2016)

MeSH Terms

Animals0Mice09,10-Dimethyl-1,2-benzanthracene0Cell Lineage0Genes, ras0Hair Follicle*Keratin-190Mutation0Proto-Oncogene Proteins p21(ras)0Receptors, G-Protein-Coupled0Skin Neoplasms*Stem Cells*Membrane Glycoproteins*Nerve Tissue Proteins*Carcinogenesis*Neoplasms, Experimental0

Article Info

PMID: 42275467
DOI: 10.1126/science.adv8291

How to Cite

Kandyba E et al. Chemically induced skin tumors arise from long-lived stem cells of the upper hair follicle. Science2026;eadv8291. doi:10.1126/science.adv8291

Data Accuracy Notice: Research intelligence on Health AI Central is aggregated from public sources (PubMed, ClinicalTrials.gov, FDA, NIH, CMS, and others) and refreshed nightly. Classifications and derived metrics are produced by automated methods described in our Methodology. We recommend verifying critical data points against the primary sources before making decisions.