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Peer-Reviewed Publication
Insights Imaging2026;17(1)June 9, 2026Journal Article

Toward a standardized and interoperable imaging biomarker catalog.

Pablo Rodríguez-Belenguer1, Paula Doria-Borrell1, Ángel Alberich-Bayarri2, Raquel Perez-Lopez3, Vicky Goh4, Konstantin Nikolau5, Aad van der Lugt6, Marion Smits6,7, Luis Rodríguez-Rodríguez8, Leonor Cerdá-Alberich9, Luis Martí-Bonmatí1
1Biomedical Imaging Research Group (GIBI230), Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain.
2Quibim-Quantitative Imaging Biomarkers in Medicine, Valencia, Spain.
3Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
4Department of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
5Department of Radiology, University of Tuebingen, Tuebingen, Germany.
6Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
7Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
8Musculoskeletal Pathology Group, Rheumatology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
9Biomedical Imaging Research Group (GIBI230), Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain. leonor_cerda@iislafe.es.

Abstract

INTRODUCTION: Imaging biomarkers are quantifiable features extracted from medical images that indicate health status, disease characteristics, or treatment response. Their value depends on rigorous standardization and validation-efforts advanced by QIBA and EIBALL. Variability in existing inventories highlights the need for a FAIR (Findable, Accessible, Interoperable, Reusable)-compliant catalog t…

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