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Peer-Reviewed Publication
Cogn Neurodyn2026;20(1):107.December 1, 2026Journal Article

Eligibility-trace-gated depression in predecessor feature learning enables post-reward exploration.

Incheol Seo1,2,3, Sun-Hyun Park4, Hyunsu Lee5,6,7
1Department of Immunology, School of Medicine, Kyungpook National University, Gukchaebosang-Ro, Daegu, 41944 Republic of Korea.
2Clinical Omics Institute, Kyungpook National University, Daegu, 41405 Republic of Korea.
3Brain Korea 21 FOUR Program, School of Medicine, Kyungpook National University, Daegu, 41944 Republic of Korea.
4Division of Advanced Predictive Research, Center for Bio-Signal Research, Korea Institute of Toxicology (KIT), Daejeon, 34114 Republic of Korea.
5Department of Physiology, School of Medicine, Pusan National University, Busandaehak-ro, Yangsan, 50612 Republic of Korea.
6Medical Research Institute, School of Medicine, Pusan National University, Busandaehak-ro, Yangsan, 50612 Republic of Korea.
7Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Busandaehak-ro, Yangsan, 50612 Republic of Korea.
PubMed PMC DOI PDF

Abstract

UNLABELLED: Spatial navigation and exploration require flexible learning mechanisms that can adapt to changing environmental demands. While dopamine's role in reward prediction error is well-established, the computational functions of other neuromodulators in reinforcement learning remain less understood. Here, we investigate how acetylcholine (ACh) modulation affects predecessor feature (PF)-base…

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