A computational analysis of the glycoprotein LRP1 structure and the role of glycans as quaternary glue.

Gian Marco Tuveri¹, Marco Basile², Silvia Acosta Gutiérrez³, Marius Kausas⁴, Silvia Pujals⁵, Xiaohe Tian⁶, Giancarlo Franzese⁶, Lorena Ruiz Pérez⁷, Giuseppe Battaglia⁸

¹Institute for Bioengineering of Catalunya (IBEC), The Barcelona Institute of Science and Technology (BIST), c/ Baldiri Reixac, 10-12, 08028, Barcelona, Spain.

²Department of Biomedicine, University of Barcelona, c/ Martí i Franquès 1, 08028, Barcelona, Spain.

³InstaDeep Ltd, 1 Triton Square, NW1 3BF, London, United Kingdom.

⁴Vianautis Bio ltd, Cadence, Unity Campus, CB22 3FT, Cambridge, United Kingdom.

⁵Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia, c/ Jordi Girona, 18-26, 08034, Barcelona, Spain.

⁶Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology and National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, 610000, Sichuan Province, China.

⁷Department of Applied Physics, University of Barcelona, c/ Martí i Franquès 1, 08028, Barcelona, Spain.

⁸Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluís Companys 23, 08010, Barcelona, Spain.

PubMed DOI

Abstract

MOTIVATION: The low-density lipoprotein receptor-related protein 1 (LRP1) plays a critical role in development and transport across the blood-brain barrier (BBB), yet its molecular architecture has remained unresolved due to the absence of an experimentally determined structure. RESULTS: Using homology modelling and neural network-based structure prediction algorithms, complemented with molecular…

Create a free account to keep reading

Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.

Create Free Account Sign In

Want unlimited research access? See Pro plans

Data Accuracy Notice: Research intelligence on Health AI Central is aggregated from public sources (PubMed, ClinicalTrials.gov, FDA, NIH, CMS, and others) and refreshed nightly. Classifications and derived metrics are produced by automated methods described in our Methodology. We recommend verifying critical data points against the primary sources before making decisions.