Peer-Reviewed Publication
Sci Rep2026June 4, 2026Journal Article
Kainic acid pig model of hippocampal epilepsy.
Filip Mivalt1, Daniela Maltais2, Inyong Kim2, Jiwon Kim2, Patrik Began2, Andrea Duque Lopez2, Veronika Krakorova2, Bailey Winter2, Cheng Yen Kuo2, Shelja Sharma2, Elizabeth S Harty2, Luke H Kim2, Nicholas Gregg2, Daniel R Montonye3, Christopher K Gow3, Kai J Miller4, Jamie Van Gompel4, Kent Leyde5, Vaclav Kremen2,6, Su-Youne Chang2,3, Gregory A Worrell7
1Department of Neurology, BNEL (Bioelectronics Neurophysiology & Engineering Lab), Mayo Clinic, Rochester, MN, USA. mivalt.filip@mayo.edu.
2Department of Neurology, BNEL (Bioelectronics Neurophysiology & Engineering Lab), Mayo Clinic, Rochester, MN, USA.
3Department of Comparative Medicine, Mayo Clinic, Rochester, MN, USA.
4Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.
5Cadence Neuroscience Inc., Seattle, WA, USA.
6Department of Natural Sciences, Faculty of Biomedical Engineering, Czech Technical University in Prague, Kladno, Czech Republic.
7Department of Neurology, BNEL (Bioelectronics Neurophysiology & Engineering Lab), Mayo Clinic, Rochester, MN, USA. worrell.gregory@mayo.edu.
Abstract
Translational large-animal models that can accommodate human-scale implantable devices are essential for advancing neuromodulation therapies in epilepsy. This study establishes a kainic acid (KA)-induced porcine model of mesial temporal lobe epilepsy (mTLE) using clinical imaging, stereotactic surgery, and a fully implantable neural stimulator-recorder (INSR) device designed for humans. Seven pigs…
Create a free account to keep reading
Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.
Want unlimited research access? See Pro plans