Broussochalcone A alleviates cognitive impairment in scopolamine-induced mice as a potent β-amyloid aggregation inhibitor and changes blood and brain metabolite profiles.

Jong Min Oh¹, Won Kyeong Jeong², Hyun Ju Son², Yoon-Ju Kwon³, Seo Young Kim⁴, Tae Woo Oh⁵, Moongi Ji², Minyeong Baek⁶, Woong-Hee Shin⁶, Hee Jung Kim², Byeongchan Choi², Soo Hyun Kim³, Man-Jeong Paik⁷, Hoon Kim⁸

¹Department of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, 57922, Republic of Korea; Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju, 58245, Republic of Korea.

²Department of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, 57922, Republic of Korea.

³National Institute for Korean Medicine Development, Gyeongsan, 38540, Republic of Korea.

⁴Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu, 41062, Republic of Korea; University of Science and Technology (UST), Korean Convergence Medicine Major KIOM, Daejeon, 34054, Republic of Korea.

⁵Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu, 41062, Republic of Korea; University of Science and Technology (UST), Korean Convergence Medicine Major KIOM, Daejeon, 34054, Republic of Korea. Electronic address: taewoo2080@kiom.re.kr.

⁶Department of Biomedical Informatics, College of Medicine, Korea University, Seoul, 02708, Republic of Korea.

⁷Department of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, 57922, Republic of Korea. Electronic address: paik815@scnu.ac.kr.

⁸Department of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, 57922, Republic of Korea. Electronic address: hoon@sunchon.ac.kr.

PubMed DOI

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE: Broussonetia papyrifera (BP) has been used for traditional medicine in amelioration of cognitive decline. Accumulation of β-amyloid (Aβ) plaques majorly contributed to the pathogenesis of Alzheimer's disease (AD). AIM OF THE STUDY: This study aimed to investigate the role of broussochalcone A (BCA), a bioactive constituent of BP, in alleviation of cognitive impairm…

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