Peer-Reviewed Publication
J Thorac Oncol2026;103953.June 1, 2026Journal Article
Machine Learning Assessment of Pathologic Response in Lung Cancer Resections After Neoadjuvant Therapy-IASLC MPR Project.
Sanja Dacic1, Daniel Shenker2, Mary Redman3, Lauren Brunner2, Anjali Saqi4, Wendy A Cooper5, Alain Borczuk6, Jin-Haeng Chung7, Carolyn Glass8, Javier Martin Lopez9, Anja C Roden10, Lynette Sholl11, Annikka Weissferdt12, Jacqueline Brosnan-Cashman2, Stephanie Hennek2, Sean Grullon2, Juan Posadas13, Junya Fujimoto14, Casey Connolly15, Murry W Wynes15, Beatriz Sanchez-Espiridion13, J Jack Lee16, Sabina Berezowska17, Teh-Ying Chou18, Keith Kerr19, Andrew G Nicholson20, Kurt A Schalper21, Ming-Sound Tsao22, Neal Ready23, Tina Cascone24, John Heymach24, Boris Sepesi25, Catherine Shu26, Naiyer Rizvi26, Joshua Sonett27, Nasser Altorki28, Mariano Provencio29, Paul A Bunn30, Mark G Kris31, William Travis32, Limin Yu2, Ignacio Wistuba13,
1Department of Pathology, Yale School of Medicine, New Haven, Connecticut. Electronic address: sanja.dacic@yale.edu.
2PathAI, Inc., Boston, Massachusetts.
3Fred Hutchinson Cancer Center, Seattle, Washington.
4Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.
5Tissue Pathology and Diagnostic Oncology, NSW Health Pathology, Royal Prince Alfred Hospital, Faculty of Health and Medicine, University of Sydney, Faculty of Medicine, University of Western Sydney, Sydney, Australia.
6Department of Pathology and Laboratory Medicine, Northwell Health, Lake Success, New York.
7Department of Pathology and Translational Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
8Department of Pathology, Duke University School of Medicine, Durham, North Carolina.
9Department of Pathology, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
10Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
11Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
12Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
13Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
14Clinical Research Center in Hiroshima, Department of Medical Informatics, Hiroshima University Hospital, Department of Translational Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
15International Association for the Study of Lung Cancer, Denver, Colorado.
16Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
17Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
18Taipei Veterans General Hospital, Taipei, Taiwan.
19Department of Pathology, Aberdeen Royal Infirmary, Aberdeen University Medical School, Aberdeen, Scotland, United Kingdom.
20Department of Histopathology, Royal Brompton and Harefield National Health Service Foundation Trust and National Heart and Lung Institute, Imperial College, London, United Kingdom.
21Department of Pathology, Yale School of Medicine, New Haven, Connecticut.
22Department of Pathology, University Health Network and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
23Department of Medicine, Duke Medical Center, Durham, North Carolina.
24Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
25Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
26Division of Hematology and Oncology, Columbia University Medical Center, New York, New York.
27Thoracic Surgery Department, Columbia University New York-Presbyterian Hospital, New York, New York.
28Department of Cardiothoracic Surgery, Weill Medical College of Cornell University, New York, New York.
29Department of Medical Oncology, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
30Division of Medical Oncology, University of Colorado School of Medicine, Aurora, Colorado.
31Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York, New York.
32Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Abstract
INTRODUCTION: Machine learning algorithms may improve the efficiency and accuracy of pathologic response (PR) assessment in surgically resected lung cancers after neoadjuvant therapy. The aim of this study was to develop digital models for quantifying tumor bed (TB) area and residual viable tumor (VT) and to compare these results to previously published assessments of PR by pathologists from the I…
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