Effects of apolipoprotein E ε4 on amyloid deposition and relative cerebral perfusion in cognitively normal individuals: a dual-phase 18F-florbetaben PET study.

Ji-Young Kim¹, Donghyeon Kim², Geon Ha Kim³, Hai-Jeon Yoon¹

¹Department of Nuclear Medicine, Ewha Womans University, College of Medicine.

²Research Institute, Neurophet Incorporation.

³Department of Neurology, Ewha Womans University, College of Medicine, Seoul, Republic of Korea.

PubMed DOI

Abstract

OBJECTIVES: Apolipoprotein E (APOE) genotypes, amyloid burden, and relative cerebral perfusion surrogate provide crucial insights into Alzheimer's disease pathophysiology. This study aimed to investigate the effects of APOE ε4 on relative perfusion and amyloid deposition in cognitively normal individuals using dual-phase 18F-florbetaben PET. METHODS: Cognitively normal subjects who underwent dual…

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