Fluid Volumes Longitudinal Modeling to Predict Atrophy and Fibrosis in Neovascular Age-Related Macular Degeneration.

Stefano Mercuri^1,2, Stefan Sacu¹, Sophie Frank-Publig¹, Johannes Schrittwieser¹, Markus Gumpinger¹, Oliver Leingang³, Ursula Schmidt-Erfurth¹, Usha Chakravarthy⁴, Hrvoje Bogunovic⁵, Gianni Virgili^2,6, Gregor S Reiter¹

¹Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.

²Department of Neurosciences, Psychology, Drug Research, and Child Health, Eye Clinic, University of Florence, AOU Careggi, Florence, Italy.

³RetInSight GmbH, Vienna, Austria.

⁴Center for Experimental Medicine, Institute of Clinical Science, Queen's University Belfast, Belfast, UK.

⁵Center for Medical Data Science (Institute of Artificial Intelligence), Medical University of Vienna, Vienna, Austria.

⁶IRCCS - Fondazione Bietti, Rome, Italy.

PubMed PMC DOI PDF

Abstract

PURPOSE: To evaluate the impact of retinal fluid volumes on the development of atrophy and fibrosis in neovascular age-related macular degeneration (nAMD) during routine care. DESIGN: Retrospective longitudinal study. PARTICIPANTS: Treatment-naïve eyes with nAMD from the Vienna Imaging Biomarker Eye Study (2007-2018), initiating anti-VEGF therapy. METHODS: Volumes of intraretinal fluid (IRF), s…

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