A Molecular Hybrid for Double Stepwise Nitric Oxide Photorelease with Double Fluorescence Readout in Living Cells.

Cristina Parisi¹, Francesca Laneri¹, Anna Di Porzio², Barbara Melilli³, Danilo Aleo³, Antonio Randazzo², Fabiana Quaglia², Salvatore Sortino¹

¹Laboratory of Photochemistry, Department of Drug and Health Sciences, University of Catania, Viale Andrea Doria 6, Catania I-95125, Italy.

²Department of Pharmacy, University of Napoli Federico II, Via Domenico Montesano 49, Napoli I-80131, Italy.

³MEDIVIS S.r.l., Tremestieri Etneo, Catania 95030, Italy.

PubMed PMC DOI PDF

Abstract

The strict dependence of the multifaceted biological effects of nitric oxide (NO) on the generation site and dose demands precise spatiotemporal control of its delivery. Light-activatable NO precursors enable this requirement by allowing for the appropriate localization of the excitation light source on the area of interest and regulation of the light dose. However, monitoring the NO released in l…

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