Peer-Reviewed Publication
Neuromuscul Disord2026;64106459.May 22, 2026Journal Article
Quantitative whole-body MRI in FSHD: assessing systemic involvement and future directions.
Seth D Friedman1, Doris Leung2, Lara Riem3, Olivia DuCharme3, Kathryn Eve Costanzo3, Emma Weatherley4, Allison N McCrady5, Anna Faino6, Leo H Wang7, Dennis W W Shaw8, George H J Shaw9, Jeff Statland10, Silvia S Blemker11
1Seattle Children's Hospital, Seattle, WA, USA. Electronic address: seth.friedman@seattlechildrens.org.
2Kennedy Krieger Institute, Baltimore, MD USA.
3Springbok Analytics, Charlottesville, VA, USA.
4FSHD Global Research Foundation, Sydney, Australia.
5University of Virginia, Charlottesville VA, USA.
6Seattle Children's Hospital, Seattle, WA, USA.
7University of Washington, Seattle WA, USA.
8Seattle Children's Hospital, Seattle, WA, USA; University of Washington, Seattle WA, USA.
9Friends of FSH Research, Seattle WA, USA.
10University of Kansas Medical Center, Kansas City, KS USA.
11Springbok Analytics, Charlottesville, VA, USA; University of Virginia, Charlottesville VA, USA.
Abstract
Facioscapulohumeral muscular dystrophy (FSHD) is a progressive, highly variable disease marked by asymmetric and time-varying muscle degeneration. This review distills ten lessons learned from the evolution of magnetic resonance imaging (MRI) in FSHD, focusing primarily on quantitative whole-body MRI (WBMRI) using chemical-shift-based water-fat-separation imaging (Dixon) two-echo methods. A descri…
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