Mesenchymal Stromal Cell-Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration.

Xingyu Liu^1,2, Edgar E Perez Carbajal^1,3, Yih-Chii Hwang⁴, Sahil A Mapkar^1,2, Benjamin W Gilman¹, Sarah A Bliss¹, Lam B Tran¹, Kalgi T Mehta¹, Jacob O Banyasz¹, Ming Yu¹, Reynold R Liu¹, Matthew N Ly¹, Christapher S Morrissey⁴, Michael N Wosczyna^1,2,3,5

¹Department of Orthopedic Surgery, New York University Grossman School of Medicine, New York City, New York, USA.

²Department of Biomedical Engineering, New York University Tandon School of Engineering, Brooklyn, New York, USA.

³Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.

⁴DNAnexus, Mountain View, California, USA.

⁵Helen L. & Martin S. Kimmel Center For Stem Cell Biology, New York University Grossman School of Medicine, New York City, New York, USA.

PubMed PMC DOI PDF

Abstract

Mesenchymal stromal cells (MSCs) support tissue homeostasis and regeneration, yet their molecular signals remain largely enigmatic. In skeletal muscle (SkM), MSCs, known as fibroadipogenic progenitors (FAPs), are essential for maintenance and repair, orchestrating these processes through intricate cellular communication networks. Given the critical role of SkM in lifelong health and longevity, FAP…

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