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Diabetes Technol Ther2026;15209156261451052.May 28, 2026Journal Article

Increased Glycation Ratio and Risk of Complications in Latent Autoimmune Diabetes in Adults Compared With Type 1 Diabetes Onset before 30 Years: A Cohort Study.

Sandra Herranz-Antolín1,2, Fernando Gómez-Peralta3, Xu Yongjin4, María Asunción Martínez-Brocca5, Gloria Cánovas-Molina6, Aurora Aragón-Alonso7, Miguel Brito-Sanfiel8, Jose Ignacio Martínez-Montoro9, Virginia Bellido10, Sharona Azriel11,12, María Del Carmen López-García13, Cristina Tejera14, Amparo Bartual15, Verónica Perea16, Pedro José Pines13, Antonio J Amor17,18, Óscar Moreno-Pérez19,20, Rebeca Reyes-García21, Gema López-Gallardo10, María Durán-Martínez22, Cristina Serrano3, Rosa Márquez-Pardo23, Noemí González-Pérez de Villar24, Manuel Gargallo25,26, Estefanía Santos27, Pedro Pujante28, Jessica Ares28, Diego Bellido14, Ignacio Conget17, Yaghoub Dabiri4, Timothy C Dunn4
1Guadalajara University Hospital, Guadalajara, Spain.
2IDISCAM, Castilla-La Mancha Health Research Institute, Guadalajara, Spain.
3Segovia General Hospital, Segovia, Spain.
4Abbott Diabetes Care, Alameda, California, USA.
5Virgen de la Macarena Hospital, Sevilla, Spain.
6Fuenlabrada University Hospital, Fuenlabrada, Spain.
7Virgen de la Arrixaca University Hospital, Murcia, Spain.
8Puerta de Hierro University Hospital, Madrid, Spain.
9Virgen de la Victoria University Hospital, Málaga, Spain.
10Virgen del Rocio University Hospital, Sevilla, Spain.
11Infanta Sofía University Hospital, San Sebastián De Los Reyes, Spain.
12European University of Madrid, Madrid, Spain.
13Albacete University Hospital Complex, Albacete, Spain.
14Ferrol University Hospital Complex, Ferrol, Spain.
15Valencia University Clinical Hospital, Valencia, Spain.
16Mutua Terrassa University Hospital, Barcelona, Spain.
17Clinic Hospital, Barcelona, Spain.
18CIBERDEM. Biomedical Research Network Center for Diabetes and Associated Metabolic Diseases, Carlos III Health Institute (ISCIII), Madrid, Spain.
19Dr. Balmis University General Hospital, Alicante, Spain.
20ISABIAL. Alicante Institute for Health and Biomedical Research, Alicante, Spain.
21Torrecárdenas University Hospital, Almería, Spain.
22Getafe University Hospital, Getafe, Spain.
23Juan Ramón Jiménez University Hospital, Huelva, Spain.
24La Paz University Hospital, Madrid, Spain.
25Infanta Leonor Hospital, Madrid, Spain.
26Fundación Jiménez Díaz University Hospital, Madrid, Spain.
27Burgos University Hospital, Burgos, Spain.
28Asturias Central University Hospital, Oviedo, Spain.
PubMed DOI

Abstract

OBJECTIVE: To clarify the distinctions between Latent Autoimmune Diabetes in Adults (LADA) and Type 1 diabetes (T1D) diagnosed < 30 years using continuous glucose monitoring (CGM) metrics, glycation rate, and risk of complications. DESIGN AND METHODS: Multicenter, cross-sectional, observational study including subjects with T1D onset < 30 years (T1D cohort) and those classified as LADA diagnosed…

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