A Twin-Fluid Atomization Method for Fabricating Ovalbumin-Loaded Gelatin Microcapsules.

Toru Taharabaru¹, Ryohei Noge², Ayumi Goto¹, Honami Michiwaki¹, Masahiro Ogura¹, Takahiro Endo², Masato Takahashi^1,2, Taishi Higashi¹, Keiichi Motoyama¹

¹Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.

²TOYO CAPSULE Co., Ltd., 560 Nakazato-Higashi-cho, Fujinomiya, Shizuoka 418-0046, Japan.

PubMed DOI

Abstract

Gelatin is an attractive wall material for microcapsule fabrication because it enables solvent-free processing. However, conventional gelatin microcapsules typically require chemical crosslinkers for structural stabilization, which may raise safety concerns and compromise the bioactivity of encapsulated protein therapeutics or antigens. Herein, we report a crosslinker-free method for fabricating g…

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