Health AI Central
Peer-Reviewed Publication
Res Sq2026May 12, 2026Journal Article

Life Stressors in Young Americans are Linked via Asymmetric U-Shapes to Mental Health Severity.

Dmitry Scherbakov1, Nina de Lacy2, Olga Barg3, Jihad S Obeid1, Alexander V Alekseyenko1
1Medical University of South Carolina.
2University of Utah.
3University of Pennsylvania School of Medicine.
PubMed PMC DOI PDF

Abstract

OBJECTIVE: To assess whether adolescent and young adult life stressors predict midlife depression/anxiety symptoms. METHODS: Using The National Longitudinal Survey of Youth 1997 (n = 8,984; ages < 35 exposures; ages > 35 outcomes), we modeled maximum scores on CES-D/GAD-7 scales with stratified random forests and visualized via accumulated local effects. The U-shaped association was confirmed wit…

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