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Peer-Reviewed Publication
BMC Pulm Med2026May 19, 2026Journal Article

Classification and regression trees to identify COPD subgroups in clinical trial populations: insights from the IMPACT trial.

Lucile Regard1,2,3, Jean-Louis Paillasseur4,5, Pierre-Régis Burgel6,7,4, Nicolas Roche6,7,4
1APHP Centre, Respiratory Medicine Department, Cochin Hospital, Paris, 75014, France. lucile.regard@aphp.fr.
2University Paris Cité, INSERM UMR 1016, Institut Cochin, Paris, 75014, France. lucile.regard@aphp.fr.
3Initiatives BPCO research group, Paris, 75006, France. lucile.regard@aphp.fr.
4Initiatives BPCO research group, Paris, 75006, France.
5Effi-Stat, Paris, 75004, France.
6APHP Centre, Respiratory Medicine Department, Cochin Hospital, Paris, 75014, France.
7University Paris Cité, INSERM UMR 1016, Institut Cochin, Paris, 75014, France.
PubMed PMC DOI PDF

Abstract

BACKGROUND: Heterogeneity in chronic obstructive pulmonary disease (COPD) challenges the identification of optimal treatment populations. Subgroups derived from real-life cohorts using classification and regression trees (CARTs) have shown prognostic value for mortality, but their applicability to clinical trial populations to predict treatment response needs to be further investigated. We sought…

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