Peer-Reviewed Publication
Cell Cycle2026;25(1):2630878.December 1, 2026Journal Article
Circular RNAs in tumorigenesis: an insight into recent research in biogenesis and targeted tumor therapy.
Zahra Shafaghat1, Pezhman Golshanrad2, Saber Saharkhiz3, Anna Leśniak4, David Mikeladze5,6, Nelly Datukishvili5,6, Marzieh Ramezani Farani7, Iraj Alipourfard4
1Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
2Department of Computer Engineering, Sharif University of Technology (International Campus), Tehran, Iran.
3Division of Neuroscience, Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
4Department of Pharmacotherapy and Pharmaceutical Care, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.
5Laboratory of Genome Structure and Function, Ivane Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.
6School of Natural Sciences and Medicine, Ilia State University, Tbilisi, Georgia.
7Nano Bio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University, Inha-ro, Incheon, Republic of Korea.
Abstract
Circular RNAs (circRNAs) are eukaryotic RNA molecules that are covalently closed and have the characteristics of high stability, tissue-specific expression, and cell-specific expression. The majority of circRNAs are produced from pre-mRNAs that also result in linear RNA, and they have expression patterns that are similar to those of their host mRNAs. Despite their abundance, circRNAs are typically…
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