Peer-Reviewed Publication
Allergy2026;81(7):2478-2489.July 1, 2026Journal Article
Rapid Human Skin Barrier Disruption by Sodium Dodecyl Sulfate and Associated Molecular Mechanisms.
Manru Li1, Huseyn Babayev1, Paolo D'Avino1, Can Zeyneloğlu1, Ceren Bicer1, Duygu Yazici1, Yagiz Pat1, Per Svedenhag2, Nicolas Gaudenzio3,4, Cezmi A Akdis1,5, Yasutaka Mitamura1,6,7
1Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
2SciBase AB, Sundbyberg, Sweden.
3University of Toulouse, Inserm, CNRS, Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), Toulouse, France.
4Genoskin SAS, Toulouse, France.
5Christine Kühne - Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.
6Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
7Department of Dermatology, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan.
Abstract
BACKGROUND: Epithelial barrier disruption is a hallmark of allergic skin diseases. Sodium dodecyl sulfate (SDS), a surfactant in household cleaning products, is known to impair the barrier.
METHODS: We used a physiologically relevant ex vivo human skin combined with real-time electrical impedance spectroscopy (EIS) to monitor barrier integrity after SDS exposure. Multi-omics analyses, including R…
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