Peer-Reviewed Publication
PLOS Digit Health2026;5(5):e0001360.May 1, 2026Journal Article
Retinal biological age correlates with bone mineral density and fracture risk score and predicts incident osteoporosis.
Qingsheng Peng1,2, Can Can Xue1, Kenon Chua2,3, Hengtong Li4, Simon Nusinovici1,5, Zhi Da Soh1, Preeti Gupta1, Ah Young Leem6, Marco C Y Yu1,5, Charumathi Sabanayagam1,5, Tyler Hyungtaek Rim5,6, Zhuoting Zhu7, Ecosse Lamoureux1,5, Ching-Yu Cheng1,8,4,5
1Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
2Clinical and Translational Sciences Program, Duke-NUS Medical School, Singapore, Singapore.
3Department of Orthopedic Surgery, Singapore General Hospital, Singapore, Singapore.
4Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
5Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.
6Mediwhale Inc., Seoul, Republic of Korea.
7Center for Vision Research Australia, Melbourn, Australia.
8Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Abstract
Osteoporosis often lacks accessible screening tools, leading to underdiagnosis and increased fracture risk. We explored the potential of a retinal aging biomarker, measured by the RetiAGE algorithm, in stratifying osteoporosis risk. Cross-sectional and prospective cohort study. The retinal biological aging biomarker, RetiAGE, indicates the probability of being older than 65 years, was derived from…
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