Health AI Central
Peer-Reviewed Publication
Eye (Lond)2026;40(12):1806-1814.August 1, 2026Clinical Trial Protocol

I-SCREEN: Development of an AI-based infrastructure for community-wide screening and prediction of progression in age-related macular degeneration providing accessible shared care.

Marie Louise Enzendorfer1, Gregor S Reiter2, Hrvoje Bogunović3, Sophie Riedl2, Julia Mai2, Johannes Schrittwieser2, Christoph Stapf2, Virginia Mares2, Matjaž Mihelčič4, Julie-Anne Little4,5, Polona Jaki-Mekjavić6,7,8, Daniel Barthelmes9, Katja Hatz10,11, Javier Zarranz-Ventura12,13, Catherine Creuzot-Garcher14,15, Ruth Hogg16, Amir Sadeghipour17, Ursula Schmidt-Erfurth18,
1Laboratory for Ophthalmic Image Analysis (OPTIMA), Medical University of Vienna, Vienna, Austria.
2Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
3Institute of Artificial Intelligence, Center for Medical Data Science, Medical University of Vienna, Vienna, Austria.
4European Council of Optometry and Optics, Adligenswil, Switzerland.
5Centre for Optometry and Vision Science, School of Biomedical Sciences, Ulster University, Coleraine, UK.
6Department of Ophthalmology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
7Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
8Jozef Stefan Institute, Ljubljana, Slovenia.
9Department of Ophthalmology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
10Vista Augenklinik Binningen, Binningen, Switzerland.
11Faculty of Medicine, University of Basel, Basel, Switzerland.
12Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.
13Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FCRB-IDIBAPS), Barcelona, Spain.
14University Bourgogne Europe, Dijon, France.
15Ophthalmology Department, Dijon University Hospital, Dijon, France.
16Centre for Public Health, School of Medicine, Dentistry, and Biomedical Science, Queen's University Belfast, Belfast, UK.
17RetInSight GmbH, Vienna, Austria.
18Laboratory for Ophthalmic Image Analysis (OPTIMA), Medical University of Vienna, Vienna, Austria. ursula.schmidt-erfurth@meduniwien.ac.at.
PubMed PMC DOI PDF

Abstract

OBJECTIVES: This work describes the design and methodological framework of the I-SCREEN project, which aims to develop an artificial intelligence (AI)-based infrastructure utilising optical coherence tomography (OCT) for early detection of AMD and assessment of progression risk. METHODS: The pan-European project is conducted across clinics and optometry/optician practices in six European countrie…

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