FEA-guided co-design of bubble microneedles: controlled tip separation for rapid transdermal and sublingual delivery.

Changzhao Jiang¹, Jing Yang², Mengxuan Gao¹, Yi He¹, Weiwei Liao¹, Hang Chen¹, Zhixiong Wang¹, Shibo Ying¹, Xiaohua Tao³, Xiumei Jiang¹, Jincui Ye¹

¹Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Institute of Materia Medica, Hangzhou Medical College, Hangzhou, People's Republic of China.

²Collaborative Innovation Center of Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of China.

³Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, People's Republic of China.

PubMed PMC DOI PDF

Abstract

Separable bubble microneedles (BMNs) incorporate an internal cavity that enables tip-confined loading and controlled tip-baseplate separation, yet their design has largely relied on empirical iteration. Here, we present a finite element analysis (FEA)-guided co-design framework that co-optimizes BMN geometry, cavity parameters, and matrix properties to enable controlled tip-baseplate separation wh…

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