q3-MuPa: Quick, quiet, quantitative multi-parametric MRI using physics-informed diffusion models.

Shishuai Wang¹, Florian Wiesinger², Noemi Sgambelluri³, Carolin Pirkl², Stefan Klein³, Juan A Hernandez-Tamames³, Dirk H J Poot³

¹Erasmus University Medical Center, Dr. Molewaterplein 40, Rotterdam, 3015 GD, The Netherlands. Electronic address: s.wang@erasmusmc.nl.

²GE HealthCare, Oskar-Schlemmer-Straße 11, Munich, 80807, Germany.

³Erasmus University Medical Center, Dr. Molewaterplein 40, Rotterdam, 3015 GD, The Netherlands.

PubMed DOI

Abstract

MuPa-ZTE is a novel multi-parametric quantitative MRI protocol that enables fast and nearly silent scanning. However, accelerating multi-parametric acquisitions to meet clinical time constraints makes the reconstruction of accurate and clean qMRI maps increasingly challenging, particularly under severe undersampling and noise. In this work, we propose a physics-informed diffusion model for MuPa-ZT…

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