RENAsym, a quantitative systems toxicology platform model, designed to predict drug-induced kidney injury indicates polymyxin B and valproate overdose toxicity potential while simultaneously demonstrating acetaminophen and valproate safety at therapeutic levels.

Celeste Vallejo¹, Pallavi Bhargava¹, Nader Hamzavi¹, Matthew McDaniel¹, Vinal V Lakhani¹, Timothy Qi¹, Christina Battista¹, Lara Clemens¹, Lisl K M Shoda¹, Zackary R Kenz¹, Shailendra Tallapaka¹, Yeshitila Gebremichael¹, Jeffrey L Woodhead¹

¹Simulations Plus, Research Triangle Park, NC 27709, United States.

PubMed PMC DOI PDF

Abstract

RENAsym is a quantitative systems toxicology (QST) modeling platform designed to predict drug-induced kidney toxicity. The model includes the proximal tubule cell (PTC) life cycle, regeneration of PTCs, sodium reabsorption, nephron death, and drug-induced injury and inflammation within the proximal tubules. The mechanisms of drug-induced toxicity included are overproduction of reactive oxygen spec…

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