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Peer-Reviewed Publication
Cancer Epidemiol Biomarkers Prev2026May 5, 2026Journal Article

The landscape of genomic and socioeconomic variables in colorectal cancer patients based on genetic ancestry.

Preethi Srinivasan1, Sara L Bristow2, Fernando L Mendez2, Shifra Krinshpun2, Adham Jurdi2, Minetta C Liu1, Matthew Rabinowitz3, Jeffrey Wall4, Carlos D Bustamante4, Alexander G Ioannidis5, Francisco M De La Vega5, Breeana L Mitchell6, Alexey Aleshin7, Johannes G Reiter2
1Natera (United States) San Carlos, CA United States.
2Natera (United States) Austin, TX United States.
3Natera (United States) Austin United States.
4Galatea Bio, Inc. Hialeah, FL United States.
5Stanford Medicine Stanford, CA United States.
6Natera United States.
7Natera (United States) San Carlos, California United States.
PubMed DOI

Abstract

BACKGROUND: Despite differences in tumor alterations across genetic ancestries, investigations of the colorectal cancer (CRC) molecular landscape have used self-reported ethnicity instead of genetic ancestry. METHODS: We used tumor and matched normal whole-exome sequencing data from 16,388 stage I-IV CRC patients to investigate CRC's germline and somatic molecular landscape and the potential infl…

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