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Peer-Reviewed Publication
Microorganisms2026;14(4)April 7, 2026Journal Article

The Human Gut Microbiome Activity Is Resilient and Stable for up to Six Months: A Large Stool Metatranscriptomic Study.

Ryan Toma1, Lan Hu2, Nan Shen2, Eric Patridge2, Robert Wohlman3, Guruduth Banavar2, Momchilo Vuyisich1
1Viome Life Sciences, Inc., Bothell, WA 98011, USA.
2Viome Life Sciences, Inc., New York, NY 10018, USA.
3Washington Gastroenterology, Bellevue, WA 98004, USA.

Abstract

The human microbiome influences health and disease through diverse biochemical and functional outputs (e.g., enzymes, structural proteins, metabolites, and other cellular components) that affect nearly every aspect of human physiology. Metatranscriptomics (MT), an unbiased RNA sequencing approach, is a high-throughput and high-content method that quantifies both gut microbial taxonomy and active b…

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