Choriocapillaris Flow Deficits Are Spatially Linked to Retinal Pigment Epithelium and Photoreceptor Integrity in Geographic Atrophy.

Lukas Kuchernig¹, Gregor S Reiter¹, Johannes Schrittwieser¹, Anna Eidenberger¹, Natasa Jeremic¹, Markus Gumpinger¹, Hrvoje Bogunovic², Ursula Schmidt-Erfurth¹, Stefan Sacu¹

¹Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.

²Center for Medical Data Science (Institute of Artificial Intelligence), Medical University of Vienna, Vienna, Austria.

PubMed PMC DOI PDF

Abstract

PURPOSE: To assess the correlation between choriocapillaris (CC) flow deficits and structural biomarkers of outer retinal degeneration in eyes with geographic atrophy (GA) secondary to nonexudative age-related macular degeneration, using a novel histology-informed binarization method and multimodal image registration. METHODS: Patients with GA underwent spectral-domain optical coherence tomograph…

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