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Peer-Reviewed Publication
J Subst Use Addict Treat2026;188209993.September 1, 2026Journal Article

A relational agent for treating substance use in adults: A randomized controlled trial with a psychoeducational comparator.

Judith J Prochaska1, Maggie Wang2, Amy Chieng3, Jessie Moore3, Erin A Vogel4, Michael Baiocchi5, Sarah Pajarito6, Maddison C Pirner6, Lauren Bullard6, Alison Darcy6, Athena Robinson6
1Stanford Prevention Research Center, Department of Medicine, School of Medicine, Stanford University, United States. Electronic address: jpro@stanford.edu.
2Department of Epidemiology & Population Health, School of Medicine, Stanford University, United States.
3Stanford Prevention Research Center, Department of Medicine, School of Medicine, Stanford University, United States.
4TSET Health Promotion Research Center, University of Oklahoma Health Sciences Center, United States.
5Department of Biomedical Data Science, Stanford University, United States.
6Woebot Health, United States.

Abstract

BACKGROUND: Highly accessible and scalable, digital mental health interventions can reduce barriers associated with traditional treatment. Woebot for Substance Use Disorders (W-SUD) is a smartphone application in development that uses Woebot, a guided self-help relational agent intended to offer support to track and reduce problematic substance use. Two formative studies supported W-SUD's feasibil…

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