Multi-walled carbon nanotube buckypaper with covalently bound NAD+ and immobilized glucose dehydrogenase for reagentless glucose biosensing.

Tomasz Rębiś¹, Sebastian Abarca², Raul Moscoso², Claudia Yáñez², Juan A Squella³

¹Redox Processes Research Center (CiPRex) and Organic and Physical Chemistry Department, Faculty of Chemical and Pharmaceutical Sciences, University of Chile Postal code, Santiago, 838492, Chile; Institute of Chemistry and Technical Electrochemistry, Faculty of Chemical Technology, Poznan University of Technology, Berdychowo 4, Poznan, PL-60965, Poland. Electronic address: tomasz.rebis@put.poznan.pl.

²Redox Processes Research Center (CiPRex) and Organic and Physical Chemistry Department, Faculty of Chemical and Pharmaceutical Sciences, University of Chile Postal code, Santiago, 838492, Chile.

³Redox Processes Research Center (CiPRex) and Organic and Physical Chemistry Department, Faculty of Chemical and Pharmaceutical Sciences, University of Chile Postal code, Santiago, 838492, Chile. Electronic address: asquella@ciq.uchile.cl.

PubMed DOI

Abstract

We report a novel bioelectrode architecture for glucose detection, integrating multi-walled carbon nanotube buckypaper (BP), glucose dehydrogenase (GDH), and covalently immobilized NAD+. The BP was first functionalized with nordihydroguaiaretic acid (NDGA), a naturally occurring quinone, to introduce redox-active anchoring sites. Subsequently, an electrochemical Michael addition of 3-aminophenylbo…

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