A Novel Breast Arterial Calcification Age-Based Percentile Nomogram for the Incremental Prediction of Incidental Cardiovascular Events.

Nitesh Nerlekar¹, Cheng Hwee Soh², Sheran Vasanthakumar³, Vinay Goel⁴, Richard Mantey⁵, Junhao Wang⁵, Emma Aldous⁴, Rhea Nandurkar⁴, Clare G Arnott⁶, Quan M Bui⁷, Alyssa Watanabe⁸, Matthew Nudy⁹, Stephen J Nicholls⁴, Lori B Daniels¹⁰, Thomas H Marwick¹¹

¹Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia; Victorian Heart Hospital, Melbourne, Victoria, Australia; Victorian Heart Institute, Melbourne, Victoria, Australia; Research Team, CureMetrix, San Diego, California, USA.

²Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.

³Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia; Victorian Heart Hospital, Melbourne, Victoria, Australia; Victorian Heart Institute, Melbourne, Victoria, Australia.

⁴Victorian Heart Hospital, Melbourne, Victoria, Australia; Victorian Heart Institute, Melbourne, Victoria, Australia.

⁵Research Team, CureMetrix, San Diego, California, USA.

⁶The George Institute for Global Health, Sydney, New South Wales, Australia; Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia; Department of Cardiology, RPA Hospital, Sydney, New South Wales, Australia.

⁷Division of Cardiovascular Medicine, University of California-San Diego, La Jolla, California, USA.

⁸Research Team, CureMetrix, San Diego, California, USA; Department of Radiology, University of Southern California Keck School of Medicine, Los Angeles, California, USA.

⁹Department of Medicine and Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania, USA.

¹⁰Division of Cardiovascular Medicine, University of California-San Diego, La Jolla, California, USA; Division of Preventive Medicine, University of California-San Diego, La Jolla, California, USA.

¹¹Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia; Menzies Institute for Medical Research, Hobart, Tasmania, Australia. Electronic address: tom.marwick@baker.edu.au.

PubMed DOI

Abstract

BACKGROUND: Breast arterial calcification (BAC) detected on routine mammography is an emerging marker of cardiovascular risk in women. However, substantial age-related variability limits its clinical interpretability. Age-adjusted nomograms may improve risk stratification and communication. OBJECTIVES: This study aims to determine whether age-adjusted BAC percentiles derived from mammography pred…

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