A Simulation-Free Radiation Therapy Workflow Using Synthetic Computed Tomography Generated from Diagnostic Magnetic Resonance Imaging for Personalized Hippocampal-Sparing Whole-Brain Treatment.

Liyuan Chen¹, Zohaib Iqbal², Weiguo Lu¹, Chenyang Shen¹, Tu Dan², Michael Dohopolski¹, Zabi Wardak², David Sher², Shahed Badiyan², Robert Timmerman², David Parsons², Andrew Godley², Steve Jiang¹, Mu-Han Lin³

¹Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas; Medical Artificial Intelligence and Automation (MAIA) Lab, UT Southwestern Medical Center, Dallas, Texas.

²Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas.

³Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas; Medical Artificial Intelligence and Automation (MAIA) Lab, UT Southwestern Medical Center, Dallas, Texas. Electronic address: mu-han.lin@utsouthwestern.edu.

PubMed DOI

Abstract

PURPOSE: The conventional computed tomography (CT)-based consultation to simulation process for hippocampal-sparing whole-brain radiation therapy (HS-WBRT) typically requires several days, delaying treatment initiation for patients who would benefit from expedited care. We developed a simulation-free, magnetic resonance imaging (MRI)-only workflow for HS-WBRT to accelerate treatment start and main…

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