Glucagon-like peptide-1: a critical link between gut microbiota dysbiosis and degenerative musculoskeletal diseases.

Wenxing Yang^1,2,3, Cong Hao^1,2,3, Ning Wang^1,2,3, Jie Xie^1,2,3, Bin Zhou^2,3, Zidan Yang^2,3, Aojie Zheng^1,2,3, Jie Wei^1,2,3,4,5, Changjun Li^2,3,6, Cen Xie^7,8, Hui Li^1,2,3, Guanghua Lei^1,2,3,5,9, Chao Zeng^1,2,3,4,9

¹Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, People's Republic of China.

²Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, People's Republic of China.

³Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, People's Republic of China.

⁴Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, People's Republic of China.

⁵FuRong Laboratory, Changsha, Hunan, People's Republic of China.

⁶Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital, Central South University, Changsha, People's Republic of China.

⁷State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China.

⁸School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.

⁹National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, People's Republic of China.

PubMed PMC DOI PDF

Abstract

Degenerative musculoskeletal diseases are characterized by the progressive loss of structural integrity and functional capacity in muscles, bones, joints, and other related tissues. These conditions primarily include osteoarthritis, osteoporosis, sarcopenia, and intervertebral disc degeneration. These diseases progress gradually, leading to chronic pain, impaired mobility, and a significantly elev…

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