Brain endothelial tmTNFα overexpression in a mouse model altered cell type-specific signaling changes linked to schizophrenia-relevant behaviors.

Jun Sang Yu¹, Minji Kim², Jaesuk Yun¹, Seong Hee Jeon², Dong Ju Son¹, Sang-Bae Han¹, Maree J Webster³, Lydia Kim³, Jin Tae Hong¹, In Jun Yeo⁴, Sanghyeon Kim⁵

¹College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju, Chungbuk 28160, South Korea.

²College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, South Korea.

³Stanley Brain Research Laboratory, Stanley Medical Research Institute, 9800 Medical Center Drive, Rockville, MD 20850, USA.

⁴College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, South Korea. Electronic address: brightline@knu.ac.kr.

⁵Stanley Brain Research Laboratory, Stanley Medical Research Institute, 9800 Medical Center Drive, Rockville, MD 20850, USA. Electronic address: kims@stanleyresearch.org.

PubMed DOI

Abstract

Genes and coexpression networks related to immune and inflammatory responses are upregulated in blood and multiple brain regions of individuals with schizophrenia, yet their mechanistic contribution to disease pathophysiology remains unclear. We previously identified transmembrane TNFα (tmTNFα) in brain endothelial cells (ECs) as a potential regulator of immune-related gene networks in schizophren…

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