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Peer-Reviewed Publication
Int J Infect Dis2026;168108715.July 1, 2026Journal Article

Incidence of human papillomavirus infections in women aged 27 years and older in the US: A federated data network study.

Ellen Stein1, Kunal Saxena2, Thomas Peer1, Joseph E Tota3, Xuedan You4, Dong Wang3, Ya-Ting Chen2, K Arnold Chan1, Linda M Niccolai5
1TriNetX, LLC, Research, Cambridge, USA.
2Outcomes Research, Value & Implementation, Merck & Co., Inc., Rahway, USA.
3Epidemiology, Biostatistics and Research Decision Sciences, Merck & Co., Inc., Rahway, USA.
4Outcomes Research, Value & Implementation, Merck & Co., Inc., Rahway, USA. Electronic address: xue.dan.you@merck.com.
5Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, USA.

Abstract

OBJECTIVES: The US Advisory Committee on Immunization Practices recommends shared clinical decision-making regarding human papillomavirus (HPV) vaccination for individuals aged 27-45 years. The incidence of HPV infection in this age group is not well-understood. This study assessed anogenital HPV infection incidence in a large cohort of unvaccinated US women aged ≥27 years. METHODS: This retrospe…

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