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Peer-Reviewed Publication
Brain Commun2026;8(2):fcag074.January 1, 2026Journal Article

Plasma p-tau217 and glucose metabolism correlate in neocortical association areas in Alzheimer's disease.

Lauren N Koenig1, Hanna Huber2,3,4, Anjalika Chongtham5,6, Guglielmo Di Molfetta2, Randolph D Andrews1, Ana Lukic1, Neeva Shafiian5, Howard M Fillit7, Kaj Blennow2, Nicholas J Ashton2,8,9, Henrik Zetterberg2,10,11,12,13,14,15,16, Dawn C Matthews1, Ana C Pereira5,6,17,18
1ADM Diagnostics, Inc., Northbrook, IL 60062, USA.
2Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 43180 Mölndal, Sweden.
3Department of Translational Dementia Research, German Center for Neurodegenerative Diseases (DZNE) Bonn, 53127 Bonn, Germany.
4Clinic of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, 53127 Bonn, Germany.
5Department of Neurology, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029, USA.
6Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029, USA.
7The Alzheimer's Drug Discovery Foundation, NewYork, NY 10019, USA.
8Banner Alzheimer's Institute, University of Arizona, Phoenix, AZ 85006, USA.
9Banner Sun Health Research Institute, Sun City, AZ 85351, USA.
10Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792, USA.
11Department of Neurodegenerative Disease, UCL Institute of Neurology, London WC1N 3BG, UK.
12Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal S-431 80, Sweden.
13Department and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705-2281, USA.
14UK Dementia Research Institute at UCL, London WC1E 6BT, UK.
15Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China.
16Centre for Brain Research, Indian Institute of Science, Bangalore 560012, Karnataka, India.
17Sanford Grossman Interdisciplinary Program I Neural Circuitry and Immune Function, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029, USA.
18Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029, USA.
PubMed PMC DOI PDF

Abstract

While the biomarkers available for Alzheimer's disease are continually expanding, including clinically approved blood tests, not all of the relationships between various biomarkers have been fully elucidated. In this study, we explore how regional brain metabolism, as measured by fludeoxyglucose-18 (FDG)-PET, relates to plasma biomarkers such as p-tau217, Glial fibrillary acidic protein (GFAP), ph…

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