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Mov Disord2026April 13, 2026Journal Article

Diffusion Magnetic Resonance Imaging of Cortical Microstructure Differs in Nonmanifest and Manifest Genetic Parkinson's Disease.

Mario Torso1, Dimitra Tzaferou1, Michele Valotti1, Jamie Hardwidge1, Ian Hardingham1, Ivan Koychev1,2, Qi Guo3, Robert Comley3, Steven A Chance1, Gerard R Ridgway1
1Oxford Brain Diagnostics Ltd, Oxford, United Kingdom.
2Department of Brain Sciences, Imperial College London, London, United Kingdom.
3AbbVie Inc, North Chicago, Illinois, USA.
PubMed DOI

Abstract

BACKGROUND: Previous investigations into neurodegenerative diseases demonstrated the utility of cortical diffusivity metrics in assessing microstructural changes. OBJECTIVE: The objective of this study was to explore cortical diffusivity metrics in genetic Parkinson's disease (PD) with glucocerebrosidase 1 (GBA1) and Leucine-rich repeat kinase 2 (LRRK2) mutations, encompassing both nonmanifest ca…

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