Health AI Central
Share:
Peer-Reviewed Publication
Cancers (Basel)2026;18(7)April 7, 2026Journal Article

Comparison of Comprehensive Serum miRNA Sequencing and Apolipoprotein A2 Isoforms for Early Detection of Pancreatic Cancer.

Hirotaka Kashima1, Munenori Kawai1, Kei Iimori1, Munemasa Nagao1, Takamitsu J Morikawa2, Ryo Otomo2, Mitsuharu Hirai2, Kosuke Minaga3, Masanori Asada4, Atsushi Umemura5, Yoshito Uenoyama6, Toshihiro Morita7, Shujiro Yazumi7, Ryuki Minami8, Saiko Marui9, Yuki Yamauchi10, Yoshitaka Nakai11, Yutaka Takada12, Seiji Shio13, Takuto Yoshioka14, Naoki Kanda14, Tomonori Masuda15, Kazuyuki Nagai16, Etsuro Hatano16, Akihisa Fukuda1, Hiroshi Seno1
1Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
2Research and Development Division, ARKRAY, Inc., Yousuien-nai, 59 Gansuin-cho, Kamigyo-ku, Kyoto 606-8507, Japan.
3Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka 589-8511, Japan.
4Department of Gastroenterology and Hepatology, Japanese Red Cross Osaka Hospital, Osaka 543-8555, Japan.
5Department of Pharmacology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
6Department of Gastroenterology and Hepatology, Japanese Red Cross Wakayama Medical Center, Wakayama 640-8558, Japan.
7Department of Gastroenterology and Hepatology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka 530-8480, Japan.
8Department of Gastroenterology, Tenri Hospital, Nara 632-0032, Japan.
9Department of Gastroenterology and Hepatology, Shiga General Hospital, Moriyama 524-8524, Japan.
10Department of Gastroenterology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki 661-0892, Japan.
11Department of Gastroenterology and Hepatology, Kyoto Katsura Hospital, Kyoto 615-8256, Japan.
12Department of Gastroenterology and Hepatology, Kobe City Nishi-Kobe Medical Center, Kobe 651-2273, Japan.
13Division of Gastroenterology, Shinko Hospital, Kobe 651-0072, Japan.
14Department of Gastroenterology and Hepatology, Takatsuki Red Cross Hospital, Takatsuki 569-1096, Japan.
15Department of Gastroenterology and Hepatology, Japanese Red Cross Otsu Hospital, Otsu 520-0046, Japan.
16Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
PubMed PMC DOI PDF

Abstract

BACKGROUNDS AND AIM: Pancreatic cancer is frequently diagnosed at advanced stages, highlighting the need for biomarkers that are capable of detecting early-stage disease in asymptomatic individuals. Recently, apolipoprotein A2 isoforms (ApoA2-ATQ/AT) have been reported as a new blood biomarker for pancreatic cancer. We recently developed diagnostic models based on 100 highly expressed serum microR…

Create a free account to keep reading

Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.

Create Free AccountSign In

Want unlimited research access? See Pro plans

Data Accuracy Notice: Research intelligence on Health AI Central is aggregated from public sources (PubMed, ClinicalTrials.gov, FDA, NIH, CMS, and others) and refreshed nightly. Classifications and derived metrics are produced by automated methods described in our Methodology. We recommend verifying critical data points against the primary sources before making decisions.