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Peer-Reviewed Publication
Phys Med Biol2026;71(8)April 24, 2026Journal Article

Confounding factors in the generalisation of synthetic CT to diagnostic spine MRI.

Ryan Pollitt1, Tom P C Schlösser2, Marijn van Stralen3, Edwin H G Oei4, Joost P H J Rutges5, L Wilbert Bartels1, Peter R Seevinck1,3
1Image Sciences Institute, University Medical Centre Utrecht, Utrecht, The Netherlands.
2Department of Orthopaedics, University Medical Centre Utrecht, Utrecht, The Netherlands.
3MRIguidance B.V., Utrecht, The Netherlands.
4Radiology & Nuclear Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands.
5Orthopaedics & Sports Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands.
PubMed DOI

Abstract

Objective. Generalisation of synthetic CT (sCT) generation to diagnostic MRI data in the spine faces many challenges, particularly when aiming at accurate visualisation of pathologies for orthopaedic treatment management. In this study we assessed the effect of potential confounding factors on the performance of sCT generation from diagnostic MR images.Approach. Paired spinal diagnostic MR and CT…

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