The role of R-loops-mediated epigenetic regulation in genome stability maintenance and disease pathogenesis: a systematic review.

Zi Hao Jiang¹, Di Feng Wang², Rui Shao¹, Xing Sheng Wang¹, Zi Ren Tang¹

¹Department of Emergency Medicine, Beijing Chaoyang Hospital, Beijing Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Innovation and Translation, Capital Medical University, Beijing, China.

²Department Obstetrics and Gynecology, Zhuji Maternity and Child Health Hospital, Zhuji, China.

PubMed PMC DOI PDF

Abstract

This systematic review synthesizes current evidence linking R-loops - associated processes with epigenetic regulation, genome stability, and human disease, integrating findings across DNA/RNA/protein modifications and 3D genome organization, and highlighting key mechanistic and technical gaps relevant to future studies, including longer-term translational exploration. Following PRISMA guidelines (…

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